Guide to Microtomes: Exploring the Microtome Machines, Types, Blades, Uses, and Prices

Subarna Debbarma (BPT, DNHE)

A microtome mechine on a table

Table Of Content 

What is Microtome Mechine ?
Microtome Uses 
Microtome Types
Microtome knife
Microtome Price

What is Microtome Mechine ?

A microtome is a device used in laboratories to cut thin slices of tissue for microscopic examination.

Microtome Uses 

Microtomes are essential tools in histology, pathology, and other scientific fields.Uses of microtomes include:

1. Histological Analysis: Microtomes are used to prepare thin sections of tissue samples for microscopic examination. This helps researchers and pathologists study the structure and cellular composition of tissues.

2. Medical Diagnostics: Microtomes play a crucial role in diagnosing diseases by allowing pathologists to examine tissue samples and identify abnormalities.

3. Research: Microtome prepared tissue sections are used in various scientific studies to investigate cellular structures, disease mechanisms, and tissue reactions.

4. Pharmaceutical Development: Microtomes are used in drug development to study the effects of compounds on tissues, helping researchers understand potential drug interactions and side effects.

5. Education: Microtomes are used in educational settings to teach students about tissue anatomy, histology, and microscopy.

6. Forensic Science: Microtomes aid in examining tissue samples for forensic purposes, such as identifying cause of death or analyzing evidence in criminal investigations.

7. Quality Control: Microtome prepared sections are used for quality control in industries like textiles, polymers, and food, to assess material properties.

8. Plant and Animal Studies: Microtomes are used to prepare sections of plant and animal tissues for research in fields like botany, zoology, and ecology.

9. Electron Microscopy: Ultra microtomes are used to create extremely thin sections for electron microscopy, allowing researchers to study subcellular structures in high detail.

10. Art Conservation: Microtomes can be used to create thin sections from historical artifacts, helping conservators analyze materials and deterioration.

Microtome Types

1. Rotary Microtome: This type of microtome uses a rotary motion to cut tissue sections. It is suitable for routine histology work and can produce thin, consistent slices.

2. Cryostat Microtome: Designed for cutting frozen tissue samples, a cryostat microtome maintains low temperatures to prevent distortion during slicing.

3. Vibrating Microtome: This microtome uses vibrations to cut sections. It's often used for delicate or soft tissues, as it reduces compression artifacts.

4. Sliding Microtome: It employs a sliding mechanism for cutting sections. Sliding microtomes are used for larger tissue samples and are known for their versatility.

5. UltraMicrotome: This specialized microtome is used for cutting ultra-thin sections (typically for electron microscopy) and requires advanced skills.

6. Automatic Microtome: These microtomes are motorized and automated, making the slicing process more precise and efficient.

Microtome knife

A microtome knife, also known as a microtome blade, is a critical component of a microtome used for cutting thin sections of tissue samples. These blades are designed to produce precise and consistent cuts, allowing researchers and pathologists to prepare tissue sections for microscopic examination. Microtome knives come in various shapes, sizes, and materials to accommodate different types of tissues and cutting requirements.

Microtome Price

The price of a microtome can vary widely based on factors such as the brand, model, features, and specifications. Basic manual microtomes can start at a few $100 dollars, while more advanced models with motorized or automated functions can range from a $1000 - $10000 dollars.

In india microtome price: 35,000 Rupees - 3 lakhs  Rupees.

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